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Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and so it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that since right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug can also raise hypertension and pulse rate, and mustn't be used in individuals with a history of cardiac event or stroke in the previous six months. 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